Our Competencies

At Biohagen Labs, we empower your biotech and pharma breakthroughs with deep expertise and advanced, hands-on science. Here’s what we can do for you:

    • Unbiased off-target assessment and orthogonal validation for gene editing programs

    • On-target efficacy profiling with quantitative assays for editing outcomes and functional impact

    • Comparative platform evaluation to support informed selection of nuclease, base editor, or other editing architectures

    • Analytical workflows and reporting aligned with development-stage decision-making and IND-enabling needs

    • Assay development and experimental support for emerging gene editing technologies, including new editor classes and recombinase-based systems

    • Advanced DNA cloning, mutagenesis, and knock-in/knock-out strategies

    • Custom plasmid design, in vitro transcription (IVT), and RNA synthesis (mRNA, circRNA, ncRNA)

    • Lentiviral and retroviral transduction for complex experiment

    • Recombinant protein production (bacterial and insect systems)

    • Development and optimization of custom immunoassays, enzymatic assays, and ELISA/AlphaLISA platforms

    • High-content and high-throughput screening with automated liquid handling

    • Expertise in cell culture, transfection, transduction, and electroporation

    • Assays for cell proliferation, viability, apoptosis, invasion, and phenotype

    • Cell sorting, differentiation, and subcellular fractionation

    • Custom assays for drug response monitoring and mode-of-action studies

    • CRISPR-based genetic screening, drug resistance models, and genetic complementation

    • Advanced phenotypic, transcriptional, replicational, and translational analyses

    • Protein purification, characterization, and drug-target engagement (NanoBRET, TSA, CETSA, MST)

    • Identification of drug-interacting proteins and complex partners

    • Creation of disease models using CRISPR, RNAi, and overexpression

    • Isogenic cell pair generation and functional analysis for drug screening and disease modeling

    • End-to-end NGS: RNA/DNA isolation, library prep, sequencing (WGS, exome, RNA-seq, ChIP-seq, ATAC-seq, more)

    • Epigenomics, transcriptomics, and CRISPR gene editing analysis

    • Custom multi-omics data analysis pipelines and advanced computational solutions

    • Database mining and user-friendly software tool development